琼脂
中文名称
琼脂
英文名称
agar
中文别名
石花菜;冻粉;琼胶
英文别名
Agar-agar; agar-agar flake; agar-agar gum; Bengal gelatin; Bengal gum; Bengal isinglass; Ceylon isinglass; Chinese isinglass; E406;gelosa; gelose; Japan agar; Japan isinglass; layor carang.
化学
CAS注册
9002-18-0
唯一成分标识(UNII)
89T13OHQ2B
分子
(C12H18O9)x
分子量及其分
结构
功能与应

Agar is a dried, hydrophilic, colloidal polysaccharide complex extracted from the agarocytes of algae of the Rhodophyceae. The structure is believed to be a complex range of polysaccharide chains having alternating a-(1→3) and b-(1→4) linkages. There are three extremes of structure noted: namely neutral agarose; pyruvated agarose having little sulfation; and a sulfated galactan. Agar can be separated into a natural gelling fraction, agarose, and a sulfated nongelling fraction, agaropectin[1].

[1] 美国FDA批准药物非活性成分数据库

琼指可用作食品增稠剂、蚕丝上浆剂、缓泻剂,以及药品的胶粘剂、增稠剂和胶囊,还可作为细菌培养基、固定化酶载体、细菌的包理材料和电泳的介质。还可用于病毒,亚细胞粒子和大分子的过滤分离,以及血清抗原或抗体的观察。ADI(每日允许摄入量)不需要特殊规[1]

Agar is widely used in food applications as a stabilizing agent. In pharmaceutical applications, agar is used in a handful of oral tablet and topical formulations. It has also been investigated in a number of experimental pharmaceutical applications including as a sustained-release agent in gels, beads, microspheres, and tablets.It has also been reported to work as a disintegrant in tablets.Agar has been used in a floating controlled-release tablet; the buoyancy in part being attributed to air entrapped in the agar gel network. It can be used as a viscosity-increasing agent in aqueous systems. Agar can also be used as a base for nonmelting, and nondisintegrating suppositories. Agar has an application as a suspending agent in pharmaceutical suspensions.

Emulsifying agent; stabilizing agent; suppository base; suspending agent; sustained-release agent; tablet binder; thickening agent; viscosity-increasing agent[2].

[1] 以上信息来自化工字典:http://www.cnreagent.com/source/sdict.php

[2] 美国FDA批准药物非活性成分数据库

给药途径
稳定性和贮藏条件
Agar solutions are most stable at pH 4–10. Agar should be stored in a cool, dry, place. Containers of this material may be hazardous when empty since they retain product residues (dust, solids)[1]. [1] 美国FDA批准药物非活性成分数据库
安全
Agar is widely used in food applications and has been used in oral and topical pharmaceutical applications. It is generally regarded as relatively nontoxic and nonirritant when used as an excipient. LD50 (hamster, oral): 6.1 g/kg LD50 (mouse, oral): 16.0 g/kg LD50 (rabbit, oral): 5.8 g/kg LD50 (rat, oral): 11.0 g/kg[1] [1] 美国FDA批准药物非活性成分数据库
配伍禁忌
Agar is incompatible with strong oxidizing agents. Agar is dehydrated and precipitated from solution by ethanol (95%). Tannic acid causes precipitation; electrolytes cause partial dehydration and decrease in viscosity of sols[1]. [1] 美国FDA批准药物非活性成分数据库
常用量及最用量
来源与制
琼脂是组成石花菜、江蓠等红藻类的细胞壁的一种粘性物质。制造条状琼脂时,用水浸泡石花菜除去杂质,用硫酸或乙酸在120℃、约0.1MPa(表压)、pH3.5-4.5条件下加热水解,将水解液过滤净化,在15-20℃冷却凝固,凝胶切条后在0-10℃下晾干即成。制造粉状琼脂时,于凝胶切条后,在13℃冻结,分离,溶解,用水调成6-7%浓度的胶液,在85℃下喷雾干燥即得。为改善产品的性能,可用碱液处理,除去部分硫酸酯基,以增加3,6-脱多-L-半乳糖含量。产品规格:GB1975-80。 【以上信息来自化工字典:http://www.cnreagent.com/source/sdict.php】
管理情况
GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral tablets). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in nonparenteral medicines licensed in the UK[1]. [1] 美国FDA批准药物非活性成分数据库
信息提供单位
北京大学医学部
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